P40 - Double-blind, placebo-controlled, food challenges (DBPCFC) of a strong tasting food: lessons learned
نویسندگان
چکیده
Methods 9 children (1.1-4.7 yr) with documented IgE-mediated cow milk (CM) allergy participated. DBPCFC were performed over a 3-d period in hospital using procedures described by Sampson et al (J Pediatr;118:520). A DBPCFC was performed on each of the first 2 d. Day 3, an open challenge of EF was done. Challenges were 100 mL of placebo (P) formula (Nutramigen liquid, Mead Johnson Nutritionals, Evansville, IN) or EF (Nutramigen containing 8 g freeze-dried Similac Alimentum, Abbott Nutrition (AN), Columbus, OH). Flavoring (chocolate or strawberry syrup) was optional and, if chosen, used in all challenges.
منابع مشابه
Molecular and immunological characterisation of peanut ingredients for double blind placebo controlled food challenge (DBPCFC)
Background Double blind placebo controlled food challenge (DBPCFC) is the gold standard for food allergy diagnosis and outcome measure. However, one difficulty in performing DBPCFC is the lack of well-characterised and validated sources of allergens for incurrence into the challenge food vehicle. Here, we discuss the requirements for this characterisation using the peanut flour used during the ...
متن کاملRecipes for use in DBPCFC and the importance of blinding
One of the crucial features of double-blind, placebocontrolled food challenge test (DBPCFC) is sufficient blinding of the allergenic food. Blinding is important to avoid any bias during the food challenge. Neither the patient nor the health care professionals involved in the test should be able to identify when the placebo or active test food are being administered. Only if this is guaranteed, ...
متن کاملPD25 - Diagnostic specificity of symptoms seen in Double Blind Placebo Control Food Challenges (DBPCFCs). Do subjective symptoms lead to false positive test results and overdiagnosis?
Background The double-blind placebo-controlled food challenge (DBPCFC) is considered to be the gold standard for diagnosing food allergy in children. During the DBPCFC, both objective and subjective symptoms are observed. Although subjective symptoms are thought to be less specific than objective symptoms, it is not known whether objective symptoms have a stronger association with a true positi...
متن کاملDouble-blind food challenges in children in general paediatric practice: useful and safe, but not without pitfalls.
OBJECTIVE To describe results of double-blind placebo-controlled food challenges (DBPCFC) with cow's milk, hen's egg, soy, peanut and hazelnut in general paediatric practice. METHODS Food challenges were performed between January 2006 and June 2011, in children 0-18 years of age, on two half-day hospital admissions with a one-week interval. Tests were performed in a double-blind fashion follo...
متن کاملDouble blind, placebo controlled food reactions do not correlate to IgE allergy in the diagnosis of staple food related gastrointestinal symptoms.
BACKGROUND The mechanisms for adverse reactions to foods in the gastrointestinal tract are poorly understood. There is conflicting evidence in the literature on the role for IgE mediated allergy in gastrointestinal reactions to staple foods. AIM The aim was therefore to study the role of IgE mediated allergy in a group of patients with a history of gastrointestinal symptoms related to staple ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014